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The polypharmacy of the AIDS patient Peter Di Giulio from San Francisco, who suffers from weight loss, chronic diarrhea, skin ailments, and neuropathy, even exceeds that 1 ; Fogelman et al., 1994 ; of Kramer. At an annual cost of j ust over $41, 000, Di Giulio has no choice but to organize his life around his medications: the DNA chain terminators d4T, 3TC; Cytovene for cytomegalovirus ; and Zovorax for herpes the protease inhibitor Crixivan; the antifungals Diflucan and Septra for PCP anti-mycobacterials Biaxin and Myambutol; the antidiarrheal Lomotil; Valium for anxiety; and an assortment of ten vitamins and supplements Tuller, 1996 ; . The polypharmacy against AIDS also extends to HIV-positive children. The treatments prescribed to an American group of 20 boys and 22 girls with an average age of 11 years serve as an example. These children were originally diagnosed as HIV-positive only at 7 years of age or later, but were HIV-positive from birth due to perinatally acquired HIV Grubman et al., 1995 ; . At the time of HIV diagnosis, 5 of 42 12% ; had some AIDS-defining disease. Yet all but two of the children were put on anti-HIV AIDS drugs: Most of the children are receiving multiple chronic medications, with 90.5% 38 of 42 ; receiving antiretroviral therapy; 78.6% 33 of 42 ; receiving PCP prophylaxis; 33.3% 14 of 42 ; receiving fungal prophylaxis; and 23.8% 10 of 42 ; receiving herpesvirus prophylaxis. Among the children receiving antiretroviral therapy, 78.9% 30 of 38 ; are receiving zidovudine [AZT]. Other medications frequently prescribed include meter dose inhalers for reactive airway disease in 33.3% 14 of 42 ; of patients and nutritional supplements for failure to thrive and wasting syndrome in 52.4% 22 of 42 ; of patients. Only 2 of the 42 children in the cohort are not receiving any medications, with 4 receiving one medication; 14 receiving two; 10 receiving between 3 and 5; and 12 receiving between 6 and 12 different medications daily. Sixty-two percent 26 of 42 ; the children receive monthly intravenous infusions of immunoglobulin Grubman et al., 1995 ; . A similar study evaluated the safety and efficacy of a three drug regimen in a small group of maternally infected infants -who had no disease Luzuriaga et al., 1997 ; . The asymptomatic patients were eight babies, 2 to 8 months old, who were experimentally treated for six months with two DNA chain terminators, AZT and didanosine, and a protease inhibitor without clinically important adverse effects.
Once a claim for Medicare benefits is submitted, Medicare will make an initial determination on the claim within 30 days of receiving the claim. 79 You will receive a written notice of this "initial determination, " called a Medicare Summary Notice "MSN" ; . This notice will tell you whether or not Medicare will pay for the services and how much you must pay. If Medicare will not pay for the services, the MSN should provide the reason why coverage was denied. 80 If you are not satisfied with Medicare's determination, you can appeal. As stated above, there are potentially five different levels of appeal. 81.
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