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Apotex, Inc., and the Apotex lawsuit has led to the interesting result mentioned above. To avoid infringement of the hemihydrate patent, Apotex reverted to the anhydrous form of the drug, maintaining its stability in ways other than by hydration. The anhydrous form contains a small percentage of the hemihydrate, however, whose presence is the result of crystal phase transitions initiated by seeding from minute amounts of the hemihydrate in the manufacturing facility in which the drug is made. The seeding was not only unintentional and undesired for purposes of patent infringement but also essentially unavoidable since it could arise from the atmosphere in the facility in amounts so small that they were undetectable. The wide-ranging economic implications of the case produced a multitude of arguments from both sides, and the judge responded with a 67-page opinion. The question of whether the unintentional and relatively small amount of hemihydrate in the otherwise anhydrous product was enough to constitute infringement was only one of the issues, but one that represents a relatively new approach to assessing patent infringement. Testimony in the case revealed that the effective seeding of hemihydrate in the anhydrous product could be caused by as few as ten molecules. Thus, any worker having previous exposure to a laboratory where the hemihydrate was produced could have introduced the hemihydrate at a level that could not have been removed with even the most scrupulous cleaning, much less detected in the facility or on the worker's person. Testimony also revealed that the slight amounts of hemihydrate in the product offered no benefit to Apotex since the hemihydrate and the anhydrate had identical therapeutic properties and the presence of the hemihydrate and ovral.
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