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The PK drug-drug interaction between L-dopa and benserazide was used together with modeling- and across species scaling techniques to investigate the hypotheses of the present thesis. PK drug-drug interactions are numerous, occur at different sites in the body, and several strategies and methods are available to determine them during drug development and post-marketing. This chapter gives an overview of all these aspects providing a broad background in which the interaction L-dopa benserazide is set. There is an introduction Chapter 1.4.1 ; , followed by a description of mechanisms resulting in PK drug-drug interactions interactions. Chapter 1.4.2 ; and strategies methods to determine PK interactions Chapter 1.4.3 ; . A brief summary Chapter 1.4.4 ; concludes the chapter on PK drug-drug.
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