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In the six newborns. In conclusion, anastrozole does not sufficiently suppress estradiol levels in women with breast cancer undergoing controlled ovarian stimulation and thus is not an alternative to letrozole. Because recent studies showed no impact of letrozole on fetal development when used as an ovulation induction agent, research should continue to test this drug's ability to make embryo or oocyte cryopreservation safer for breast cancer patients.
We are just beginning to see patients who have been treated with two or three years of adjuvant anastrozole and then relapsed. Currently, there is very little data on treatment options in this setting. It's kind of a "dealer's choice" because there are no hard-and-fast rules. There are multiple options including fulvestrant, exemestane and even tamoxifen -- if the patient hasn't seen it -- because it's obviously still a very useful drug. So the sequence is going to be all over the map for most folks.
Illness Any bodily sickness or disease, including any congenital abnormality of a newborn child, as diagnosed by a Physician and as compared to the person's previous condition. Pregnancy of a covered Employee or covered Spouse will be considered to be an Illness only for the purpose of coverage under this Plan. In-Network Services Services provided by or treated as provided by ; a Health Care Provider that is a member of the Plan's Exclusive Provider Organization EPO ; , as distinguished from Out-of-Network Services that are provided by a Health Care Provider that is not a member of the EPO Network. Injury Any damage to a body part resulting from trauma from an external source. Inpatient Services Services provided in a Hospital or other Specialized Health Care Facility during the period when charges are made for room and board. Investigational See the definition of Experimental and or Investigational. Legend Drug Means a drug which cannot be purchased without a prescription from a duly licensed physician practitioner. Maintenance Care Services and supplies provided primarily to maintain, support and or preserve a level of physical or mental function rather than to improve such function. Maintenance Medication Any prescription drug covered under this rider and listed on the MaxorPlus maintenance drug list used to treat chronic conditions. Managed Care Procedures designed to help control health care costs by avoiding unnecessary services or services that are more costly than others that can achieve the same result. Massage Therapy.
Adult dose 60 kg: 400 mg po bid with meals for 28 d; 14 d after receiving treatment, may repeat 28-d cycle for a total of 3 cycles 60 kg: 15 mg kg d po in divided doses intracerebral echinococcal cysts: 200 mg po tid for 90 d described in a single patient ; pediatric dose not established 60 kg: 15 mg kg d po in divided doses suggested dosage ; contraindications interactions pregnancy c - safety for use during pregnancy has not been established and arava.
1. Early Breast Cancer Trialists' Collaborative Group: Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28, 896 women. N Engl J Med 1988, 319: 1681-1692. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N: Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 study. J Natl Cancer Inst 1998, 90: 1371-1387. The ATAC Trialist Group: Anastroozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002, 359: 21312139. IBIS Working Party: First results from the IBIS-I breast cancer prevention trial. Lancet in press ; . Nolvadex Adjuvant Trial Organisation: Controlled trial of tamoxifen as adjuvant agent in management of early breast cancer. Lancet 1983; i: 257-261. Cuzick J, Baum M: Tamoxifen and contralateral breast cancer [letter]. Lancet 1985, 2: 282. Sismondi P, Biglia N, Volpi E, Giai M, de Grandis T: Tamoxifen and endometrial cancer. Ann NY Acad Sci 1994, 734: 310-321. Bergman L, Beelan MLR, Gallee MPW, Hollema H, Benraadt J, van Leeuwen FE: Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Lancet 2000, 356: 881-888. Cutuli B, Petit JC, Fricker JP, Jung GM, Schumacher C, Velten M, et al.: Adjuvant tamoxifen in breast cancer treatment in postmenopausal women: occurrence of thromboembolic complications. Oncol Rep 1994, 1: 59-63. Howell A, Dowsett M: Recent advances in endocrine therapy of breast cancer. Br Med J 1997, 315: 863-866. Brown P: UK death rates from breast cancer fall by a third. BMJ 2000, 321: 849. Gottardis MM, Jordan VC: Development of tamoxifen stimulated growth of MCF-7 tumours in athymic mice after longterm anti-oestrogen administration. Cancer Res 1988, 48: 5183-5187. Van Poznak C: How are bisphosphonates used today in breast cancer clinical practice? Semin Oncol 2001, 28 suppl 11 ; : 69-74. Early Breast Cancer Trialists' Collaborative Group: Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 1998, 351: 1451-1467. Powles T, Eeles R, Ashley S, Easton D, Chang J, Dowsett M, Tidy A, Viggers J, Davey J: Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial. Lancet 1998, 352: 98-101.
Especially when a temporary nurse is involved responsible for the med pass. Review of the Resident Council Minutes for March 2004 had documented complaints regarding medication administration. Residents stated that when the night time nurses come on duty they are not getting their night time medications timely or at all, and that staff are talking on their cell phones while handing out medication and that they are concerned for their safety while nurses are on the phone and not concentrating on passing the proper medications. The Grievance Log entries show 5 incidents from 1 04 - 2 residents or family's concern regarding medications not given, medications not given timely, or errors with medications. Although these incidents were followed up on by the facility, there was no evidence that a comprehensive plan was put in place to prevent med errors from occurring again. A and atarax, for example, buy anastrozole.
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Section 5: Banned Substances Apo-Furosemide furosemide ; Apo-Hydro hydrochlorothiazide ; Apo-Indapamide indapamide ; Apo-Methazide hydrochlorothiazide ; Apo-Metoprolol metoprolol ; Apo-Metoprolol type L metoprolol ; Apo-Nadol nadolol ; Apo-Orciprenaline orciprenaline ; Apo-Pindol pindolol ; Apo-Prednisone prednisone ; Apo-Propanolol propranolol ; Apo-Sotalol sotalol ; Apo-Selegiline selegiline ; Apo-Spirozide hydrochlorothiazide, spironolactone ; Apo-Tamox tamoxifen ; Prohibited in males only ; Apo-Timol timolol ; Apo-Timop timolol ; Apo-Triazide hydrochlorothiazide, triamterene ; Aquafor xipamide ; Arimidex anastrozole ; Prohibited in males only ; Aristocort parenteal, tablet triamcinolone ; Aromasin exemestane ; Prohibited in males only ; Atenolol Balminil DM + Decongestant + Expectorant pseudoephedrine ; Balminil Decongestant pseudoephedrine ; Balminil DM + Decongestant pseudoephedrine ; Balminil Nasal Ointment ephedrine ; Bambec bambuterol ; Bambuterol Benadryl Allergy Sinus Headache pseudoephedrine ; Bendrofluazide bendroflumethiazide ; Bendroflumethiazide bendrofluazide ; Benuryl probenecid ; Benylin Codeine 3.3 mg - D-E syrup pseudoephedrine ; Benylin DM-D pseudoephedrine ; Benylin DM-D-E pseudoephedrine ; Benylin DM-D-E Extra Strength pseudoephedrine ; Benylin 4 Flu pseudoephedrine ; Benzedrex propylhexedrine ; Benzfetamine benzphetamine ; Benzhydroflumethiazide bendroflumethiazide ; Benzphetamine benzfetamine ; Benzthiazide Benuryl probenecide ; Berotec Inhalation Aerosol fenoterol ; Berotec Inhalation Solution fenoterol ; Betagan levobunolol ; Betaject betamethasone ; Betaloc metoprolol ; Betaloc Durules metoprolol ; Betaxolol Betnesol tablets betamethasone ; Betoptic betaxolol ; Bisoprolol Bolasterone Boldenone Brevibloc esmolol ; Brinaldix clopamide ; Bromantan Broncospamine reproterol ; Bumetanide Bumex bumetanide ; Buprenex buprenorphine ; Buprenorphine Burinex bumetanide ; Caffeine Calmydone etafedrine, hydrocodone ; Calmylin with codeine pseudoephedrine ; Calmylin Cough & Flu, - Syp #2, - Syp #3 pseudoephedrine ; Camphorated opium Tincture morphine ; Canrenone Cardiorapide pentetrazol, pentylenetetrazol ; Carphedon Carteolol Cartrol carteolol ; Cathine norpseudoephedrine ; Celestone Soluspan betamethasone ; Celiprolol Cheque veterinary ; mibolerone ; Chi Formula ephedrine ; Chlor-Tripolon Decongestant pseudoephedrine ; Chlor-Tripolon N.D. pseudoephedrine ; Chlormerodrine Chlorphentermine Chlortalidone Chlorpropylamphetamine Chlortestosterone Chlorthalidone Chorionic gonadotrophin hCG ; Prohibited in males only.
Lower Doses of Tamoxifen Selective Estrogen Receptor Modulators Other possible targets for BrCa prevention COX-2: over-expressed in Invasive breast Ca and DCIS direct correlation between HER-2 neu over-expression and COX-2 levels vii. Celecoxib protects against BrCa in mice with HER-2 neu overexpression viii. 3rd generation SERMs: arzoxifene ix. Aromatase inhibitors x. Gonadotropin-releasing hormone agonists xi. Retinoids xii. Deltanoids xiii. DMFO 10. What about behavior and life style interventions? 11. Conclusions a. Estrogen may hold potential harm in breast cancer b. Estrogen plus progestin probably contributes to a slightly higher risk c. Risk reduction strategies are evolving d. Tamoxifen e. Raloxifene f. Anastroaole g. Letrozole h. Ongoing Trials 12. NSABP-P2 STAR ; Study Study of Tamoxifen And Raloxifene and atorvastatin.
Bacterial Infections 790.7 assoc. with B-cell chronic lymphocytic leukemia ; Immune Globulin IGIV Bladder 188. Bleomycin, Carboplatin, Cisplatin Cyclophosphamide, 1 Docetaxel, 1 Doxorubicin, Etoposide, Fluorouracil, Gemcitabine, Ifosfamide, Interferon Alpha 2a & 2b, Methotrexate, Mitomycin, Paclitaxel, Thiotepa, Valrubicin 233.7 ; , Vinblastine Bone Lesions 170. , 198.5 Levodopa, 3 Sodium Phosphate P 32, 1 Zoledronic Acid1 Brain 191. Carboplatin, Carmustine, Cisplatin, 3 Cyclophosphamide, Dexamethasone, 1 Etoposide, Interferon Alpha 2a, Interferon Alpha-2b, Lomustine, Methotrexate, 1 Procarbazine, Temozolomide, Thalidomide, 3 xx Vincristine Breast 174. , 175. Abraxane, Aminoglutethimide, 1 Anastrozole, Bevacizumab, 1 Capecitabine, Carboplatin, Cisplatin, Cyclophosphamide, Dexamethasone, Dexrazoxane, Docetaxel, Doxorubicin, Doxorubicin, Liposomal, 1 Epirubicin Hydrochloride, Estradiol, Estradiol Valerate, Estrogens Conjugated & Esterified ; , Ethinyl, Exemestane, Fluorouracil, Fluoxymesterone, Fulvestrant, Gemcitabine, Goserelin, Ifosfamide, 1 Letrozole, Leuprolide, Lomustine, Medroxyprogesterone, Megestrol, Melphalan, Methotrexate, Methyltestosterone, Mitomycin, Mitoxantrone, 1 Nandrolone, 1 Pamidronate Disodium, 1 Paclitaxel, Paclitaxel Protein Bound, Prednisone, 5Raloxifene, 1 Tamoxifen, Testolactone, Testosterone, Thalidomide3 xx, Thiotepa, Toremifene, Trastuzumab.
October 2006 322 06 anastrozole 1mg tablet Arimidex ; AstraZeneca UK Limited Adjuvant treatment of early breast cancer in hormone receptor positive postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen anastrozole Arimidex ; is accepted for restricted use within NHS Scotland for the adjuvant treatment of early breast cancer in hormone receptor positive postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen. In a combined analysis of two trials, switching to anastrozole after 2 years of tamoxifen therapy rather than continuing with tamoxifen resulted in a 3.1% increase in event-free survival at three years follow-up. It offers an alternative to tamoxifen after initial adjuvant treatment with tamoxifen for 2-3 years and has a different adverse effects profile. Treatment with anastrozole is restricted to initiation by a breast cancer specialist. On formualry. For specialist initiation and axid.
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27 not accompanied by any waveform interval or histopathological changes and is of unknown etiology. Reproductive Toxicology Anawtrozole has been found to cross the placenta following oral administration of 0.1 mg kg in rats and rabbits. Studies in both rats and rabbits at doses equal to or greater than 0.1 and 0.02 mg kg day, respectively, administered during the period of organogenesis showed that anastrozole increased pregnancy loss increased preand or post-implantation loss, increased resorption and decreased numbers of live fetuses ; . Effects were dose related in rats. Placental weights were significantly increased in rats at doses of 0.1 mg kg day or more. Evidence of fetotoxicity, including delayed fetal development i.e. incomplete ossification and depressed fetal body weights ; , was observed in rats administered doses of 1 mg kg day. There was no evidence of teratogenicity in rats administered doses up to 1 mg kg day. In rabbits, anastrozole caused pregnancy failure at doses equal to or greater than 1 mg kg day. There was no evidence of teratogenicity in rabbits administered 0.2 mg kg day. Oral administration of anastrozole to female rats produced a high incidence of infertility at 1 mg kg day and increased pre-implantation loss at 0.02 mg kg day. These effects were related to the pharmacology of the compound and were completely reversed after a 5-week compound withdrawal period. Oncogenicity The oncogenicity study in rats at doses of 1.0 to 25 mg kg day, administered by oral gavage for up to 2 years, revealed increases in the incidence of hepatocellular adenoma and carcinoma in high dose females, uterine stromal polyps in the high dose females and thyroid adenoma in the high dose males. Dose related increases were observed in the incidences of ovarian and uterine hyperplasia in females. At 25 mg kg day, plasma AUC 0-24hr ; levels in rats were about 100 times higher than the level exhibited in postmenopausal volunteers at the recommended dose.
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Take note of the patient is taking the following: exemestane, dantrolene, cimitidine, bromocriptine, carbamazepine, clofibrate, ascorbic acid, antiobiotics, hiv medications, anastrozole, griseofulvin, hormonal drugs, cortisone, prednisolone, imipramine, hydrocortisone, isoniazid, letrozole, diabetes medicines, methotrexate, phenytoin, mineral oil, raloxifene, tamoxifen, rifampin, rifapentine, rifabutin, migraine drugs, testolacotne, thyroid hormones, theophylline, topiramate, tricylcic antidrepressants and warfarin and azelaic.
Exemestane 25 mg daily ; Letrozole 2.5 mg ; Anaetrozole 1 mg.
And letrozole, and the steroid, exemestane, has resulted in a resurgence in the use of this class of drugs in the treatment of breast cancer. Until recently, megestrol acetate was the most commonly used second-line agent in the treatment of hormone-responsive metastatic breast cancer. Two Phase III trials, however, that compared anastrozols to megestrol acetate, showed an overall survival benefit in favour of anastrazole with a hazard ratio of 0.78 P 0.025 ; .30 These encouraging results led to the initiation of trials in which the newer aromatase inhibitors were compared to tamoxifen, the standard of care, in the setting of hormone-receptor positive, locally advanced, or metastatic postmenopausal breast cancer. The results of two such trials, one based in North America31 and the other in Europe, 32 have now been reported. The data from these two trials, that were of similar design, have been pooled and show that anastrazole is at least as effective as tamoxifen for the treatment of postmenopausal women with advanced breast cancer in terms of median time to progression TTP, 8.5 months compared to 7.0 months, hazard ratio 1.12 ; . Several clinical trials designed to test the efficacy of aromatase inhibitors in preventing relapse after definitive surgery for early breast cancer are ongoing or have recently closed to accrual. One of these, the ATAC anastrazole alone, tamoxifen alone, or in combination ; trial, compared anastrazole to tamoxifen and to a combination of the two treatments. The early results of this large trial involving more than 9, 000 women were reported at the San Antonio Breast Cancer Symposium in December 2001. Over a median follow-up period of 33 months, anastrazole was associated with a 19% improvement in diseasefree survival compared to tamoxifen. The presentation of this result sparked considerable debate and has been discussed in several articles and commentaries in the oncology literature.33 The consensus is that longer follow-up is required to show whether the advantage of anastrazole over tamoxifen will be sustained over time. For now, tamoxifen is still considered by most to be the standard of care for postmenopausal breast cancer patients with steroidhormone receptor positive disease.34 and azithromycin.
In general, the process required by the fda before investigational drugs may be marketed in the united states involves the following steps: pre-clinical laboratory and animal tests; submission of an ind, which must become effective before human clinical trials may begin; 19 table of contents adequate and well-controlled human clinical trials to establish the safety and efficacy of the proposed drug for its intended use; pre-approval inspection of manufacturing facilities and selected clinical investigators; and fda approval of a nda, or of a nda supplement for subsequent indications, for example, anastroozole mechanism of action.
Remainder of the 5-year adjuvant period an `unplanned switching' strategy ; . Side-effects The following are very common: insomnia; headache; hot flushes; nausea; increased sweating; fatigue. The following are common: anorexia; depression; dizziness; carpal tunnel syndrome; abdominal pain; vomiting; constipation; dyspepsia; diarrhoea; rash; alopecia; pain; peripheral oedema. Somnolence and asthenia are uncommon. Thrombocytopenia and leucopenia are rare. The following warnings have been issued with regard to exemestane: exemestane should not be administered to patients with rare hereditary problems of fructose intolerance, glucosegalactose malabsorption or sucraseisomaltase insufficiency; exemestane contains methyl p-hydroxybenzoate, which may cause allergic reactions possibly delayed ; . The same warning concerning bone mineral density as for anastdozole see the section `Bone mineral density', p. 11 ; has also been issued for exemestane. Drug interactions The co-administration of drugs such as rifampicin, anticonvulsants e.g. phenytoin and carbamazepine ; and herbal preparations containing hypericum perforatum St John's wort ; known to induce CYP3A4 may reduce the efficacy of exemestane. Aromasin should not be co-administered with oestrogen-containing medicines. Cost A 90-tablet packet of Aromasin Pfizer's proprietary name for exemestane ; costs 266.40 net the equivalent of 82.88 for 28 tablets, or 2.96 per day and azulfidine.
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Although Tourette syndrome is defined by the presence of motor and vocal tics, it is often complicated by associated difficulties such as obsessions and compulsions, aggressive and oppositional behaviour, ADHD symptoms, mood instability, anxiety and depression. It is therefore important that the clinician considering pharmacotherapy for Tourette syndrome first identifies the target symptoms to be treated and then seeks to match the target symptom s ; with an appropriate medication. Here I concentrate on the treatment of tics, but I also mention the treatment ADHD symptoms in the context of Tourette syndrome. It is important to take into account the natural history and course of Tourette syndrome, which.
Medicare Plus Blue is a private fee-for-service plan with a Medicare contract. Prescription Blue is a prescription drug plan with a Medicare contract. Medicare Plus Blue and Prescription Blue are issued by Blue Cross Blue Shield of Michigan, a nonprofit corporation and an independent licensee of the Blue Cross and Blue Shield Association and bactrim.
Mdash; robert w carlson, md the asco technology assessment that does not support the use of adjuvant anastrozole outside a clinical trial is based on fear of the unknown in the face of the single largest clinical trial ever conducted in the adjuvant setting.
Write your answers on the answer form appearing on page 47 photocopies of the answer form are acceptable ; or on a separate sheet of paper. Mark the most appropriate answer and bromocriptine and anastrozole, for instance, anastrozole cost.
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Anastrozole belongs to a group of drugs called aromatase inhibitors ais ; and works in a different way to tamoxifen and cabergoline.
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From OECD firm-level study The most important information is information on productivity. Table C-2 shows for which countries indicators are available on labor productivity as measured by.
The overall benefits in cancers responsive to endocrine manipulation are comparable to gains from cytotoxic therapy in patients with ER positive tumours. Hormone manipulation e.g. with tamoxifen ; is beneficial in patients with ER positive tumours72, 73 Level 1 evidence ; . Current options for endocrine treatment include tamoxifen, aromatase inhibitors, progestogens, luteinising hormone releasing hormone LHRH ; analogues and oophorectomy by radiotherapy, laparoscopy or open surgery. The Early Breast Cancer Trialists' Collaborative Group EBCTCG ; oxford overview shows that women with ER negative invasive tumours derive no benefit from tamoxifen Level 1 evidence ; . Endocrine treatment should not normally commence until the oestrogen and progesterone ; receptor status has been determined. Several recent trials have reported comparing aromatase inhibitors AI s ; against standard tamoxifen therapy for 5 years in the management of postmenopausal ER positive breast cancer. The ATAC study compared 5 years anastrozole against tamoxifen or a combination of anastrozole and tamoxifen. This study showed an improved disease free survival for anastrozole when compared to tamoxifen control or the combination arm at a median follow-up of 47 months.74 The 5 year data has been recently presented and has confirmed that disease free survival was significantly better and distant recurrence rates were significantly lower in patients on anastrozole compared to patients on tamoxifen. However, overall survival benefit has not yet been demonstrated.75 The MA-17 study compared the addition of a further 5 years letrozole against placebo after completion of standard.
90. A PHASE I AND PHARMACOKINETIC PK ; TRIAL OF 2 SEQUENCE S OF BCNU AND TEMOLOZOMIDE TMZ ; IN PATIENTS WITH ADVANCED SOLID TUMORS Hammond LA, Eckardt JR, Kuhn J, Rizzo J, Johnson T, Villalona-Calero M, Tolcher A, Von Hoff DD, Rowinsky EK; Institute for Drug Development, Cancer Therapy and Research Center, University of Texas Health Science Center, San Antonio, TX TMZ decreases AGAT ; activity and enhances the effect of BCNU in vitro. When TMZ is given prior to BCNU in vitro, a synergistic effect is observed [1]; but a synergistic and less toxic effect is observed when BCNU is given prior to TMZ in vivo [2]. Objective: To determine the maximum tolerated dose MTD ; for oral TMZ in combination with BCNU for 2 sequences, reveal any sequence-dependent toxicities, characterize the PK profile of TMZ on both schedules, and preliminarily determine, for example, anastrozole tamoxifen.
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Synopsis According to the DTB, preliminary evidence suggests that adjuvant therapy with anastrozole is marginally more effective than tamoxifen in prolonging disease-free survival in postmenopausal women with primary operable hormone receptor positive breast cancer, and is less likely to cause unwanted effects such as thromboembolism and uterine cancer. However bone fractures appear more likely with anastrozole than tamoxifen. The article questions whether the marginal increase in efficacy outweighs the uncertainty about unwanted effects in the long term. The DTB concludes that in early disease, tamoxifen remains the first line adjuvant therapy however, anastrozole is an alternative when tamoxifen is contra-indicated or unsuitable because of risk of thromboembolism or suspected endometrial abnormality. In postmenopausal women with hormone receptor positive locally advanced or metastatic disease, anastrozole and letrozole appear at least as effective as tamoxifen in delaying disease progression.and would therefore seem a reasonable alternative first line option to tamoxifen in this group of women.
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Log in to read full article publication: pharma marketletter publication date: 23-jul-07 delivery: immediate online access author: company: astrazeneca plc article excerpt anglo-swedish drug major astrazeneca says that new data published in the july issue of the british journal of cancer confirm that arimidex anastrozole ; is a cost-effective treatment for early breast cancer and reveal that the cost per quality-adjusted life year gained with this drug is lower than the threshold.
The influence of five years of adjuvant anastrozole or exemestane on bone mineral density in postmenopausal women with primary breast cancer, a companion study to NCIC CTG MA.27.
Correspondence and requests for reprints to Dr Zhening Liu, Institute of Mental Health, Second Xiangya Hospital, Central South University, No.139 Renmin Zhong Road, Changsha 41001 Hunan, China 1, Tel: + 8613508489006; fax: + 07315554052; e-mail: zheningl hotmail and ProfessorTianzi Jiang, Tel: + 8610 82614469; fax: + 8610 62551993; email: jiangtz nlpr.ia.ac.cn Sponsorship: The National Basic Research Program of China 2006CB500800 ; supported this work. Received17 October 2005; revised 8 November 2005; accepted 9 November 2005.
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When these patients were censored at the time of death, the hr for time to recurrence including new tumours ; was further reduced in the anastrozole arm compared with that of tamoxifen alone hr 79, 67– 94; p 008.
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